WebMay 1, 2015 · In the small cohort of 9 patients (representing 4%) with a class-1 GEP score but positive SLNB result the prognosis did appear to be intermediate between all patients with a class-1 GEP score and all patients with a class-2 GEP score. The 5-year DFS, DMFS, and OS for this group were 53%, 53%, and 77%, respectively. WebJan 29, 2024 · When comparing GEP Class 2 to AJCC stage IIB and above in multivariate analysis, both classifications were significant predictors of recurrence, distant metastasis, and all-cause death (P ≤ .006 for all; Table 3). Only GEP Class 2 was significant for melanoma-specific death (P = .005; Table 3).
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WebOct 30, 2024 · In fact, GEP class 2 tumors are more heterogeneous cytologically, which could explain the lower accuracy on a subarea/ROI level in our class 2 samples. Given that GEP class 1 tumors typically contain a majority of less-aggressive tumor cells and vice versa for class 2 tumors, we hypothesize that our algorithm learned to equate “GEP … WebClass 2 GEP signature (p<0.001). All other clinical risk factors as well as a cumulative total risk score did not have a statistically significant association with GEP signature. WebBackground: Metastatic risk for uveal melanoma (UM) patients can be characterized by gene expression profiling (GEP) (Castle Biosciences, Friendswood, TX). Class 1A … morticia addams halloween costumes