Witryna31 sie 2002 · To gain further insight into this topic we report herein a novel approach by analyzing the role of HERG K+ channels in the regulation of hemopoietic cell … Witryna7 sty 2024 · The hERG potassium channel and hERG screening for drug-induced torsades de pointes. Pharmacol Ther 2008;119(2):118-32. 6 [6]. Witchel HJ, Milnes …

BacMam-hERG Potassium Channel

Witryna4 lip 2024 · A major physiological role of hERG1 (human Ether-á-go-go-Related Gene 1) potassium channels is to repolarize cardiac action potentials. Two isoforms, … paradiso coffee

Potassium Channel HERG - an overview ScienceDirect Topics

Witryna11 sie 2024 · The voltage-gated potassium channel, KV11.1, encoded by the human Ether-à-go-go - Related Gene (hERG) is expressed in cardiac myocytes, where it is … Witryna21 mar 2006 · hERG potassium channels are essential for normal electrical activity in the heart. Inherited mutations in the HERG gene cause long QT syndrome, a disorder … hERG (the human Ether-à-go-go-Related Gene) is a gene (KCNH2) that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart: the hERG channel … Zobacz więcej hERG forms the major portion of one of the ion channel proteins (the 'rapid' delayed rectifier current (IKr)) that conducts potassium (K ) ions out of the muscle cells of the heart (cardiac myocytes), … Zobacz więcej A detailed atomic structure for hERG based on X-ray crystallography is not yet available, but structures have recently been solved by electron microscopy. In the laboratory the Zobacz więcej This channel is also sensitive to drug binding, as well as decreased extracellular potassium levels, both of which can result in decreased channel function and drug-induced Zobacz więcej The hERG gene was first named and described in a paper by Jeff Warmke and Barry Ganetzky, then both at the University of Wisconsin–Madison. The hERG gene is the human homolog of the Ether-à-go-go gene found in the Drosophila fly; Ether-à-go-go was … Zobacz więcej Loss-of-function mutations in this channel may lead to long QT syndrome (LQT2), while gain-of-function mutations may lead to short QT syndrome. Both clinical disorders stem from ion channel dysfunction (so-called channelopathies) that can lead … Zobacz więcej Due to the documented potential of QT-interval-prolonging drugs, the United States Food and Drug Administration issued recommendations for the establishment of a cardiac safety profile during pre-clinical drug development: ICH S7B. The … Zobacz więcej HERG has been shown to interact with the 14-3-3 epsilon protein, encoded by YWHAE. Zobacz więcej paradiso cine bar