Web25 jul. 2024 · A pharmacological inhibitor of the temperature sensitive hERG (human ether-a-go-go related gene) phenocopies the excitability effects of ziram but only at elevated … WebhERG (the human Ether-à-go-go-Related Gene)，人延迟整流钾离子通道基因，是指基因KCNH2。 该基因编码的蛋白质被称为 K v 11.1，是钾离子通道(英語： potassium ion …
HERG-Kanal – Wikipedia
WebTolterodine is a first-line antimuscarinic drug used to treat overactive bladder. Adverse cardiac effects including tachycardia and palpitations have been observed, presumably … hERG (the human Ether-à-go-go-Related Gene) is a gene (KCNH2) that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart: the hERG channel … Meer weergeven hERG forms the major portion of one of the ion channel proteins (the 'rapid' delayed rectifier current (IKr)) that conducts potassium (K ) ions out of the muscle cells of the heart (cardiac myocytes), … Meer weergeven Loss-of-function mutations in this channel may lead to long QT syndrome (LQT2), while gain-of-function mutations may lead to short QT syndrome. Both clinical disorders stem from ion channel dysfunction (so-called channelopathies) that can … Meer weergeven Due to the documented potential of QT-interval-prolonging drugs, the United States Food and Drug Administration issued … Meer weergeven The hERG gene was first named and described in a paper by Jeff Warmke and Barry Ganetzky, then both at the University of Wisconsin–Madison. The hERG gene is the human homolog of the Ether-à-go-go gene found in the Drosophila fly; Ether-à-go-go was … Meer weergeven A detailed atomic structure for hERG based on X-ray crystallography is not yet available, but structures have recently been solved by electron microscopy. In the laboratory the heterologously expressed hERG potassium channel comprises 4 identical … Meer weergeven This channel is also sensitive to drug binding, as well as decreased extracellular potassium levels, both of which can result in decreased channel function and drug-induced Meer weergeven HERG has been shown to interact with the 14-3-3 epsilon protein, encoded by YWHAE. Meer weergeven haikyuu nekoma vs karasuno
Human ether-a-go-go related gene (hERG) K+ channels: function …
Web15 dec. 2010 · In vitro screens using cellular preparations expressing human Ether-à-go-go related gene (hERG) potassium channels have become an intrinsic tool for evaluating … Web27 jan. 2024 · The human ether-a-go-go-related gene HERG (encoding Kv11.1 potassium channels) is expressed in different parts of the body including the heart, pancreas and … Web2 sep. 2014 · Blockade of the cardiac ion channel coded by human ether-à-gogo-related gene (hERG) can lead to cardiac arrhythmia, which has become a major concern in drug … haikyuu nendoroid