Human ether-a-go-go-related gene
Web28 sep. 2007 · Abstract. Antipsychotic drugs are thought to exert their therapeutic action by antagonizing dopamine receptors but are also known to produce side effects in the heart by inhibiting cardiac ether-a-go-go–related gene (ERG) K + channels. Recently, it has been discovered that the same channels are present in the brain, including midbrain dopamine … WebEffects of Paroxetine on a Human Ether-a-go-go-related Gene (hERG) K+ Channel Expressed in Xenopus Oocytes and on Cardiac Action Potential,발행기관 : 대한구강생물학회,수록지정보 : International Journal of Oral Biology / 43권 1호,저자명 : Hee-Kyung Hong, Soobeen Hwang, Su-Hyun Jo
Human ether-a-go-go-related gene
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Web6 jul. 2024 · Background and Purpose. Human ether-a-go-go-related gene (hERG; K v 11.1) channel inhibition is a widely accepted predictor of cardiac arrhythmia. hERG channel inhibition alone is often insufficient to predict pro-arrhythmic drug effects. This study used a library of dofetilide derivatives to investigate the relationship between standard measures … WebAN OVERVIEW ON HUMAN ETHER-A-GO-GO-RELATED GENE ASSAY Abstract hERG (human ether-à-go-go-related gene) encodes a potassium ion channel which involved …
Web1 okt. 2024 · Amongst various ion channels in the heart, the human ether-à-go-go-related gene (hERG) channel is an important off-target for drugs that induce cardiotoxicity. … WebhERG. ヒト心臓の心筋に発現しているhERG（human ether-a-go-go related gene）から発現するタンパク質のことで，心筋活動電位の再分極を担うカリウムイオンチャネルで …
Webhuman Ether-a-go-go Related Gene) ist ein spannungsaktivierter, auswärtsgleichrichtender Kaliumkanal in Herzmuskelzellen und ... Das Gen ist verwandt mit dem bei Drosophila … WebA novel dendritic nanocarrier of polyamidoamine-polyethylene glycol-cyclic RGD for “smart” small interfering RNA delivery and in vitro antitumor effects by human ether-à-go-go …
Web3 mei 2024 · Miaomaio Liu, Yakun Yang, Muqing Zhang, Yucong Xue, Bin Zheng, Yuanyuan Zhang, Yu Liu, Xi Chu, Zhenqing Sun, Xue Han, Inhibition of human ether-à-go-go …
Web11 mrt. 2024 · The human ether-a-go-go-related gene HERG (encoding Kv11.1 potassium channels) is expressed in different parts of the body including the heart, pancreas and … lutherville physicians mercyWebCommon Pharmacophores for Uncharged Human Ether-a-go-go-Related Gene (hERG) Blockers. Journal of Medicinal Chemistry 2006, 49 (23) , 6917-6921. DOI: 10.1021/jm060500o. Andrea Cavalli,, Paolo Carloni, and, Maurizio Recanatini. Target-Related Applications of First Principles Quantum Chemical Methods in Drug Design. lutherville plumbing cohERG (the human Ether-à-go-go-Related Gene) is a gene (KCNH2) that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart: the hERG channel … Meer weergeven hERG forms the major portion of one of the ion channel proteins (the 'rapid' delayed rectifier current (IKr)) that conducts potassium (K ) ions out of the muscle cells of the heart (cardiac myocytes), … Meer weergeven Loss-of-function mutations in this channel may lead to long QT syndrome (LQT2), while gain-of-function mutations may lead to Meer weergeven Due to the documented potential of QT-interval-prolonging drugs, the United States Food and Drug Administration issued recommendations for the establishment … Meer weergeven HERG has been shown to interact with the 14-3-3 epsilon protein, encoded by YWHAE. Meer weergeven A detailed atomic structure for hERG based on X-ray crystallography is not yet available, but structures have recently been solved … Meer weergeven This channel is also sensitive to drug binding, as well as decreased extracellular potassium levels, both of which can result in decreased channel function and drug-induced Meer weergeven The hERG gene was first named and described in a paper by Jeff Warmke and Barry Ganetzky, then both at the University of Wisconsin–Madison. The hERG gene is the human homolog of the Ether-à-go-go gene found in the Drosophila fly; Ether-à-go-go was … Meer weergeven jd 310 backhoe seatWebThe human ether-a-go-go-related voltage-gated cardiac ion groove (commonly acknowledged as hERG) directs the rapid outward repolarizing potassium running in cardiomyocytes (IKr). Inadvertent blockade of this channel by drug-like minims represents a key challenge in pharmaceutical R&D due to often intersecting between the structure … lutherville plastic surgeryWebThe human ether-a-go-go related gene (hERG) encodes the inward rectifying voltage gated potassium channel in the heart (I Kr) which is involved in cardiac repolarization. … lutherville pharmacy hoursWeb1 sep. 2016 · The human ether-a-go-go-related gene ( hERG) 2 encodes the pore-forming subunit of the rapidly activating delayed rectifier K + channel (I Kr ), which plays an … lutherville personal physicians radiologyWebThe human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel (IKr), which is important for cardiac … lutherville physicians imaging