Paracellin
WebBACKGROUND: A new protein, named paracellin 1 (PCLN-1), expressed in human thick ascending limb (TAL) tight junctions, possibly plays a critical role in the control of magnesium and calcium reabsorption, since mutations of PCLN-1 are present in the … Webexplore the effect of Mg2 transport modulators on the paracellin-1 gene promoter. Endogenous paracellin-1 mRNA and protein were detected in renal cell lines opossom kidney (OK), HEK293, and MDCT, but not in the fibroblast cell line NIH3T3. A 7.5-kb hPCLN-1 5 -flanking DNA sequence along with seven 5 -deletion products
Paracellin
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WebJul 2, 1999 · Here, positional cloning has identified a human gene, paracellin-1 ( PCLN-1 ), mutations in which cause renal Mg 2+ wasting. PCLN-1 is located in tight junctions of the TAL and is related to the claudin family of tight junction proteins. These findings provide … WebOct 1, 2008 · They found that FHHNC was caused by mutations in paracellin-1, which is now considered to be claudin-16. In the past few years, research in this area has proliferated, and several comprehensive general reviews of this have recently been published (89, 99, 103). In this article, we focus on reviewing recent discoveries …
WebA new protein, named paracellin 1 (PCLN-1), expressed in human thick ascending limb (TAL) tight junctions, possibly plays a critical role in the control of magnesium and calcium reabsorption, since mutations of PCLN-1 are present in the hypomagnesemia hypercalciuria syndrome (HHS). However, no functional experiments have demonstrated that TAL ... Webg limb of Henle's loop. Mutations in PCLN-1, which encodes the renal tight junction protein paracellin-1 (claudin-16), were identified as the underlying genetic defects. Comprehensive clinical data and the results of PCLN-1 mutation analysis of 25 FHHNC families with 33 affected individuals are presented. Patients presented mainly with urinary tract infections, …
Webtermed paracellin-1 (PCLN-1), was determined (14) and sequence analysis showed that it en-codes a protein of 305 amino acids (Fig. 2A) with four transmembrane domains and intracel-lular NH 2 - and COOH-termini (11, 15). The PCLN-1 protein shows sequence … WebJun 6, 2007 · a Detection of paracellin-1 transcripts in human salivary glands by RT-PCR.A Gl.submandibularis, C Gl. parotis, E Gl. labialis, G Gl. sublingualis; B, D, F, H controls lacking reverse transcriptase.The 934 bp fragments represent the expected PCLN-1 …
WebNov 1, 2005 · Tight junctions play a key selectivity role in the paracellular conductance of ions. Paracellin-1 is a member of the tight junction claudin protein family and mutations in the paracellin-1 gene cause a human hereditary disease, familial hypomagnesemia with …
WebIn immunohistochemical studies paracellin-1 colocalised in the salivary excretory ducts with the tight junction proteins ZO-1 and occludin suggesting a potential role in paracellular calcium and magnesium transport. In the acini no such colocalisation was observed; … csn campus address north las vegasWebOct 30, 2003 · Recently, paracellin-1 was identified as a renal tight junction protein predominantly expressed in TAL. Mutations of its gene (CLDN16) have been shown to cause FHHNC. We describe a sporadic Japanese case of FHHNC. The male patient showed hematuria, hypercalciuria, and nephrocalcinosis at 5 years of age. Hypomagnesemia … csn call hoursWebRemarkably, paracellin-1 was found to be homologous to the claudin family of tight junction proteins. This discovery provides a plausible explanation for the finding that different members of the claudin family of proteins are expressed in different epithelia. Claudin 16 (or paracellin-1) is expressed in the thick ascending limb of Henle where ... csn calendar summer 2022WebJul 1, 2001 · A new protein, named paracellin 1 (PCLN-1), expressed in human thick ascending limb (TAL) tight junctions, possibly plays a critical role in the control of magnesium and calcium reabsorption ... csn campus charlestonWebDec 1, 2005 · Paracellin-1 is a member of the tight junction claudin protein family and mutations in the paracellin-1 gene cause a human hereditary disease, familial hypomagnesemia with hypercalciuria and ... csn.cancer loginWebFHHNC results from mutations in paracellin-1, a tight-junction protein that appears to be important in conducting or regulating paracellular cation transport. Impaired function of paracellin-1 leads specifically to urinary losses of magnesium and calcium, but because … csn campus locationsWebSep 15, 2000 · The paracellin-1 gene, which is the causative gene for human renal hypomagnesemia with hypercaciuria and nephrocalcinosis, encodes a tight junction protein of renal epithelial cells. Therefore, we concluded that deletion of the paracellin-1 gene is responsible for renal tubular dysplasia of cattle, and the cattle disease could be a good … eagleswood township tax collector